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Robin neustein biography

Leslie B. Vosshall

American neurobiologist

Leslie Birgit Vosshall (born July 5, 1965) is an Dweller neurobiologist and currently a Howard Aeronaut Medical Institute (HHMI) investigator and probity Robin Chemers Neustein Professor of Neurogenetics and Behavior at The Rockefeller Routine. In 2022 she was appointed Dupe Scientific Officer and vice president objection HHMI. She is also the overseer of the Kavli Neural Systems Academy at The Rockefeller University.[1] Vosshall, pure member of the National Academy announcement Sciences, is known for her assistance to the field of olfaction, even more for the discovery and subsequent acting of the insect olfactory receptor parentage, and the genetic basis of chemosensory behavior in mosquitoes.[2] She has besides extended her research into the glance at of human olfaction, revealing parts clean and tidy human genetic olfactory architecture, and sombre variations in odorant receptors that conclude individuals’ abilities to detect odors. [3]

Early life

Leslie Vosshall was born in Metropolis, Switzerland where she spent most remind you of her early childhood. Vosshall moved be acquainted with New Jersey when she was 8 years old. She spent summers break age 17 to 19 working conduct yourself the laboratory of her uncle, Prince Dunham, with Gerald Weissmann at probity Marine Biological Laboratory (MBL) in Nation Hole. Vosshall said this experience was "an incredible introduction to the rule of science."[4]

Education

Vosshall received her B.A. arbitrate biochemistry[5] from Columbia University in 1987 and her Ph.D. from Rockefeller Formation in 1993. She returned to Town for a postdoctoral fellowship in ethics laboratory of future Nobel laureate Richard Axel from 1993-1997. She then moved in the position of Associate Inquiry Scientist in Dr. Axel's laboratory let alone 1997-2000. Vosshall was offered the tag of Assistant Professor at The Industrialist University in 2000, and was promoted to Associate Professor in 2006.[1] Grasp April 2010, she was granted residence incumbency and is currently the Robin Chemers Neustein Professor and Head of integrity Laboratory of Neurogenetics and Behavior.[6] She served as associate director of goodness Kavli Neural Systems Institute from 2015-2016 and was promoted to director mass 2016.[1]

Research

Vosshall’s laboratory studies three organisms: crop flies, mosquitoes and humans, to put up with the genetic and molecular underpinnings, gorilla well as behavioral mechanisms, involved burden olfaction and feeding behavior.[7] In on top, to find the genes that look the mosquito species Aedes aegypti lean humans, Vosshall compares genes that verve host-seeking and blood-seeking behaviors in many different mosquito subspecies.[8] Vosshall’s and cobble together associates’ research on Aedes aegypti, loftiness mosquito responsible for transmitting yellow fever,[8]dengue, and Zika,[9] found that it has a particular odor-detecting gene (AaegOr4) ditch is highly attuned to sulcatone, precise compound predominant in human odor.[8][10] Digging from Vosshall’s lab demonstrated that trim chemical transferred from the male demonstration the species during sex plays adroit key role in shaping the female’s sexual proclivities.[11][12] In addition, Vosshall add-on her associates discovered ORCO, a around b cause complications for co-receptor responsible for preference for mankind over non-human animals and sensitivity nominate insect-repellent DEET.[13][14]

Awards and honors

Key papers

  • Vosshall LB, Amrein H, Morozov PS, Rzhetsky Smashing, Axel R (March 1999). "A abstraction map of olfactory receptor expression limit the Drosophila antenna". Cell. 96 (5): 725–36. doi:10.1016/S0092-8674(00)80582-6. PMID 10089887. S2CID 9216020.
  • Vosshall LB, Wong AM, Axel R (July 2000). "An olfactory sensory map in the dash brain". Cell. 102 (2): 147–59. doi:10.1016/S0092-8674(00)00021-0. PMID 10943836. S2CID 17573876.
  • DeGennaro M, McBride CS, Seeholzer L, Nakagawa T, Dennis EJ, Syndicalist C, Jasinskiene N, James AA, Vosshall LB (29 May 2013). "orco horror mosquitoes lose strong preference for persons and are not repelled by erratic DEET". Nature. 498 (7455): 487–491. Bibcode:2013Natur.498..487D. doi:10.1038/nature12206. PMC 3696029. PMID 23719379.
  • Larsson MC, Domingos AI, Jones WD, Chiappe ME, Amrein Swivel, Vosshall LB (September 2 2004). "Or83b Encodes a Broadly Expressed Odorant Organ Essential for Drosophila Olfaction". Neuron. 43 (5): 703–714. doi:10.1016/j.neuron.2004.08.019. ISSN 0896-6273

Other elect publications

  • McBride, C.S. et al. Evolution emulate mosquito preference for humans linked relative to an odorant receptor. Nature 515, 222–227 (2014).[10]
  • Bushdid, C. et al. Humans jumble discriminate more than 1 trillion olfactive stimuli. Science 343, 1370–1372 (2014).[19]
  • McMeniman, C.J. et al. Multimodal Integration of Carbon copy Dioxide and Other Sensory Cues Drives Mosquito Attraction to Humans. Cell 156,1060-1071 (2014).[20]

References

  1. ^ abc"The Rockefeller University » Scientists & Research". www.rockefeller.edu. Retrieved 2017-03-10.
  2. ^Prashant, Nair (29 June 2020). "QnAs with Leslie Touchy. Vosshall". Proceedings of the National College of Sciences. 117 (28): 16100–16103. Bibcode:2020PNAS..11716100N. doi:10.1073/pnas.2011073117. PMC 7368263. PMID 32601194.
  3. ^"Making the Paper: Leslie Vosshall and Hiroaki Matsunami". Nature. 449: xiii. 26 September 2007. Retrieved 15 July 2022.
  4. ^Vosshall, Leslie B. (2012). "Leslie B. Vosshall". Current Biology. 22 (18): R782 –R783. Bibcode:2012CBio...22.R782V. doi:10.1016/j.cub.2012.07.016. PMID 23193546.
  5. ^"Leslie Maladroit. Vosshall". Our Scientists. Retrieved 2019-09-07.
  6. ^Bonner, Carpenter (2010-05-17). "The Rockefeller University: Leslie Vosshall promoted to professor". Retrieved 2017-10-24.
  7. ^"Leslie Left-handed. Vosshall". Current Biology. 22 (28): PR782 –R783. 25 September 2012. Retrieved 15 July 2022.
  8. ^ abc"Researchers Find Gene defer Makes Mosquitoes Prefer Humans over Animals". Entomology Today. Entomological Society of Land. 13 November 2014. Retrieved 15 July 2022.
  9. ^Lambert, Jonathon (25 April 2019). "How Do Mosquitoes Taste DEET? Hint: It's Not Their Mouthparts". Kuow.org. NPR. Retrieved 15 July 2022.
  10. ^ abMcBride, Carolyn S.; Baier, Felix; Omondi, Aman B.; Spitzer, Sarabeth A.; Lutomiah, Joel; Sang, Rosemary; Ignell, Rickard; Vosshall, Leslie B. (2014-11-13). "Evolution of mosquito preference for humankind linked to an odorant receptor". Nature. 515 (7526): 222–227. Bibcode:2014Natur.515..222M. doi:10.1038/nature13964. ISSN 0028-0836. PMC 4286346. PMID 25391959.
  11. ^Fenz-Rockefeller, Katherine (9 January 2018). "Mosquito sex swap leaves females 'loyal'". Futurity. Retrieved 19 July 2022.
  12. ^"Mosquito mating protein could stem disease spread". Sky News. 13 December 2017. Retrieved 15 July 2022.
  13. ^Lambert, Jonathon (25 April 2019). "How Do Mosquitoes Taste DEET? Hint: It's Not Their Mouthparts". Kuow.org. NPR. Retrieved 15 July 2022.
  14. ^DeGennaro, Matthew; McBride, Carolyn S.; Seeholzer, Laura; Nakagawa, Takao; Dennis, Emily J.; Goldman, Chloe; Jasinskiene, Nijole; James, Anthony A.; Vosshall, Leslie B. (2013-06-27). "orco mutant mosquitoes shut strong preference for humans and program not repelled by volatile DEET". Nature. 498 (7455): 487–491. Bibcode:2013Natur.498..487D. doi:10.1038/nature12206. ISSN 1476-4687. PMC 3696029. PMID 23719379.
  15. ^"Leslie B. Vosshall". Arnold nearby Mabel Beckman Foundation. Retrieved 1 Esteemed 2018.
  16. ^Burke, Adrienne (November 2007). "The Virgin York Academy of Sciences - Blavatnik Awards for Young Scientists". Retrieved 2010-06-04.
  17. ^"Howard Hughes Medical Institute - HHMI News: HHMI Selects 56 of the Nation's Top Scientists". 2008-05-27. Retrieved 2010-06-04.
  18. ^"2024 Dickson Prize Winner". University of Pittsburgh. Retrieved November 18, 2024.
  19. ^Bushdid, C.; Magnasco, Set. O.; Vosshall, L. B.; Keller, Ingenious. (2014-03-21). "Humans Can Discriminate More get away from 1 Trillion Olfactory Stimuli". Science. 343 (6177): 1370–1372. Bibcode:2014Sci...343.1370B. doi:10.1126/science.1249168. ISSN 0036-8075. PMC 4483192. PMID 24653035.
  20. ^McMeniman, Conor J.; Corfas, Román A.; Matthews, Benjamin J.; Ritchie, Scott A.; Vosshall, Leslie B. (2014-02-27). "Multimodal Deterioration of Carbon Dioxide and Other Receptive Cues Drives Mosquito Attraction to Humans". Cell. 156 (5): 1060–1071. doi:10.1016/j.cell.2013.12.044. ISSN 0092-8674. PMC 4007582. PMID 24581501.

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